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International Immunology Advance Access originally published online on November 2, 2006
International Immunology 2007 19(1):11-18; doi:10.1093/intimm/dxl116
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© The Japanese Society for Immunology. 2006. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Heme oxygenase-1 is not required for mouse regulatory T cell development and function

Santiago Zelenay, Angelo Chora, Miguel P. Soares and Jocelyne Demengeot

Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6, Apartado 14, 2780-901 Oeiras, Portugal

Correspondence to: J. Demengeot; E-mail: jocelyne{at}igc.gulbenkian.pt

CD4 regulatory T cells (Treg) ensure peripheral tolerance to self-antigens and limit the deleterious effects associated with inflammatory and immune responses by mechanisms that remain to be fully understood. The enzyme heme oxygenase-1 (HO-1), through its known anti-inflammatory activity, is a candidate for a functional role in Treg activity. We compared wild-type and heme oxygenase-1-deficient (hmox-1–/–) mice in order to assess the role of HO-1 in mouse Treg development and function under physiologic conditions. The frequency of CD25+ and Foxp3+ Treg was similar in hmox-1–/– and hmox-1+/+ mice. More importantly, CD4+CD25+ Treg purified from either hmox-1–/– or hmox-1+/+ mice were equally efficient in controlling the proliferation in vitro and the expansion in vivo of CD4+CD25– T cells, whether or not these responder cells expressed HO-1. In addition, induction of expression of HO-1 in vivo did not affect Treg suppressor function. As shown before, expression of HO-1 was higher in Treg than in naive T cells; however, naturally activated Foxp3– T cells displayed equal amount of HO-1 mRNA as Treg. Finally, we conclude that under physiological conditions in mice, Treg development, maintenance and function are independent of HO-1 activity.

Keywords: inflammation, regulatory T cells, tolerance

Transmitting editor: R. Flavell


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